Altered by Sympathetic Denervation
نویسندگان
چکیده
With agonist stimulation, cardiac f32-adrenergic receptors (f2ARs) are downregulated to a much greater extent than are fJ1ARs. It has been hypothesized that this effect is due to sympathetic innervation inhibiting the downregulation of ,IJARs. To test this hypothesis, the technique of coverslip autoradiography was used to localize and quantify f31AR and 2AR subtypes in tissue compartments of the heart in rats subjected to sympathetic denervation by two intravenous injections of 6-hydroxydopamine (50 mg/kg per dose). After denervation, the rats were infused with L-isoproterenol (400 ,gkg-'. h` for 7 days) or vehicle (0.OO1N HCI) by implantation of osmotic minipumps. Sections were incubated with 70 pmol/L of the PAR antagonist ["'I]iodocyanopindolol (ICYP) alone or in the presence of 5 &mol/L DL-propranolol
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